TCD has its importance in diagnosis, treatment decisionmaking, and prognosis of Sickle Cell Disease. By TCD measurement of elevated blood flow velocities (BFV), children, who may benefit from blood transfusions, can be identified even months before stroke. TCD guided, intensified therapy reduces stroke risk....

SARS-CoV-2 infection can be particularly dangerous in patients whose vascular function is already impaired by pre-existing conditions. This explains the typical clinical picture by causing circulatory disorders in the heart, as well as pulmonary embolism and vascular occlusions....